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Douglas P Gladue Selected Research

African Swine Fever

12/2022Deletion of E184L, a Putative DIVA Target from the Pandemic Strain of African Swine Fever Virus, Produces a Reduction in Virulence and Protection against Virulent Challenge.
1/2022Recombinant ASF Live Attenuated Virus Strains as Experimental Vaccine Candidates.
10/2021Deletion of the A137R Gene from the Pandemic Strain of African Swine Fever Virus Attenuates the Strain and Offers Protection against the Virulent Pandemic Virus.
1/2021ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever.
1/2020Development of a Highly Effective African Swine Fever Virus Vaccine by Deletion of the I177L Gene Results in Sterile Immunity against the Current Epidemic Eurasia Strain.
1/2019Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages.
1/2017Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.
10/2016Association of the Host Immune Response with Protection Using a Live Attenuated African Swine Fever Virus Model.
6/2015African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus.
2/2015The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome.

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Douglas P Gladue Research Topics

Disease

10African Swine Fever
12/2022 - 02/2015
4Classical Swine Fever (Swine Fever)
10/2021 - 01/2016
4Infections
01/2020 - 03/2011
3Virus Diseases (Viral Diseases)
01/2022 - 01/2016
1Acute Disease
01/2022
1Vaccinia
12/2021
1Viremia
12/2021
1Swine Diseases (Disease, Swine)
01/2019
1Asymptomatic Infections
01/2018
1Pestivirus Infections
01/2014
1Diarrhea
01/2014

Drug/Important Bio-Agent (IBA)

10VaccinesIBA
12/2022 - 02/2015
7Proteins (Proteins, Gene)FDA Link
12/2022 - 01/2014
3DNA (Deoxyribonucleic Acid)IBA
12/2021 - 10/2016
1Peptides (Polypeptides)IBA
10/2021
1Viroporin ProteinsIBA
01/2018
1Marker VaccinesIBA
01/2017
1AntibodiesIBA
01/2016
1Attenuated VaccinesIBA
01/2016
1Glycoproteins (Glycoprotein)IBA
01/2014
1Antiviral Agents (Antivirals)IBA
03/2011

Therapy/Procedure

1Euthanasia (Mercy Killing)
01/2022